ZWITTERIONIC MATERIALS IN NANOMEDICINE
Shaoyi Jiang, PhD, Boeing-Roundhill Professor of Chemical Engineering & Adjunct Professor of Bioengineering, University of Washington, Seattle, WA
Thursday, March 16, 2017, 1:00 PM Eppley Science Hall (ESH 3010)
An important challenge in many applications is the prevention of nonspecific biomolecular and microorganism attachment on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level. Second, we aim to develop biocompatible ultra low fouling materials based on the molecular principles learned. As a result, we have shown that zwitterionic and mixed charge materials and surfaces are highly resistant to nonspecific protein adsorption, cell adhesion and bacteria adhesion/biofilm formation from complex media.
Zwitterionic-based polymers have now been used widely as nonfouling materials. Unlike poly(ethylene glycol) (PEG), there exist diversified zwitterionic molecular structures to accommodate various properties and applications. Furthermore, zwitterionic materials are superhydrophilic while their PEG counterparts are amphiphilic. In this talk, how zwitterionic materials stabilize nanoparticles (e.g., gold, ion oxide and quantum dot) and how zwitterionic polymer-PLGA copolymers and zwitterionic polymer-lipids form stable micelles and liposomes in complex media will be presented. Zwitterionic polymer conjugation and encapsulation of therapeutic enzymes (e.g., uricase for gout treatment) and protective enzymes (e.g., enzyme hydrolyzing organophosphates for nerve agent prophylaxis) will be further demonstrated for maintained bioactivity, prolonged circulation and minimized immunological response.
PERSONALIZED TUMOR-HOMING STEM CELL THERAPIES FOR CANCER
Shawn Hingtgen, PhD, Assistant Professor, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Friday, March 31, 2017, 12:00 PM Center for Drug Discovery and Lozier Center for Pharmacy (PDD 1002)
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