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Superparamagnetic Macromolecular-Metal Oxide Complexes for Biotechnological Applications

Judy Riffle, Ph.D., Professor, Department of Chemistry; Director, Macromolecular Science and Engineering graduate program, Virginia Polytechnic Institute and State University
March 16, 2006 11:00 a.m.  University Hospital Amphitheater UNH 4208 

Magnetic particles that display high saturation magnetization and high magnetic susceptibility are desirable for many applications in biotechnology.  Examples under current investigation include particles for cell and other molecular separations, contrast agents for MRI, field-induced tumor hyperthermia, target nanoparticles for magnetic biochip sensors, and in our case, hydrophobic magnetic fluids for treating retinal detachment.  For all of these applications, it is desirable to understand how to control dispersion and aggregation of magnetic nanoparticles by applying uniform or gradient magnetic fields.  The vast majority of magnetic biomaterials have involved iron oxides due to their oxidative stability and biological compatibility.  This lecture will address the design of both hydrophilic and hydrophobic magnetic nanoparticle structures. 

Biologically inspired engineering designs: freely-standing nanocomposite membranes for sensor arrays

Vladimir Tsukruk, Ph.D., Professor, Department of Materials Science and Engineering, Iowa State University
November 17, 2005 12:00 p.m. Bennett Hall 2020

We discuss recent results obtained in our group on assembling of freely standing membranes from ultrathin multilayered polymer-nanoparticle films (1). These films obtained via layer-by-layer assembly from oppositely charged polyelectrolytes and gold nanoparticles showed outstanding micromechanical behavior and high sensitivity to external pressure and temperature. Optical properties of arrays of membranes have been studied and these arrays are suggested as a prospective platform for acoustic, thermal, and chemical sensing as well as programmable storages for nanoscale fluidic.

Microglia as the enemy within

Howard E. Gendelman, M.D., Professor and Chair, Department of Pharmacology and Experimental Neuroscience, Larson Professor of Internal Medicine; Director, Center for Neurovirology and Neurodegenerative Disorders, UNMC
May 19, 2005  11:00 a.m.,
Eppley Science Hall Amphitheater

Creation of lactide-based copolymers bioabsorbable medical materials

Tatsuro Ouchi, Ph.D., Professor, Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka, Japan
August 11, 2004  10:00 a.m., Durham Research Center, Room 1004

Polymer Design for Nonviral Gene transfer

Kam W. Leong, Ph.D., Professor, Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University
April 21, 2005  11:00 a.m., Eppley Science Hall Amphitheater

Polymers and Molecular Imaging

Alexei A. Bogdanov, Jr., Ph.D., Associate Professor of Radiology/Chemistry, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School
March, 17, 2005  11:00 a.m., Eppley Science Hall Amphitheater

Design and application of pH-responsive polymers to enhance intracellular drug delivery

Allan S. Hoffman, Ph.D., Professor of Chemical Engineering and Bioengineering, Department of Bioengineering, University of Washington
February 17, 2005  11:00 a.m., Eppley Science Hall Amphitheater

Multifunctional pharmaceutical nanocarriers. The present and the future

Vladimir P. Torchilin, Ph.D., Distinguished Professor of Pharmaceutical Sciences, Chair, Department of Pharmaceutical Sciences,
Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University

February 16, 2006, 11:00 a.m.  University Hospital Amphitheater UNH 4208 

Ideally, drug carrier should be able: (a) to accumulate in required organ or tissue, and then (b) penetrate inside target cells delivering there its load (drug or DNA). To be able to behave this way, drug carrier should simultaneously carry on its surface various moieties capable of functioning in a certain orchestrated order. Currently, nanoparticulate delivery systems are built simultaneously capable of longevity and target recognition. In general, many other "useful" moieties can be attached to the drug carrier surface, such as diagnostic/imaging groups, cell penetrating peptide groups, stimuli-sensitive groups capable of releasing the drug under certain conditions, etc. One can think about the development of multifunctional drug delivery systems(long-circulating, specifically targeted, and capable of cell penetration) built in such a way that their certain functions may switch on and switch off under the action of specific conditions (pH, temperature) characteristic of pathological zone. Contrast/reporter group associated with such carriers can provide additional scientific or diagnostic information. Various multifunctional nanocarriers will be described for targeted drug delivery to and into various pathological cells and tissues using cancer and myocardial infarction as examples.

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