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External Advisory
Committee |
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Dr. Darrell Bigner, Duke
University Medical Center, Durham, NC
Dr. Rudy
Juliano, University of North Carolina, Chapel Hill, NC
Dr. Jindrich Kopecek, University of Utah, Salt Lake City, Utah
Dr. Robert Langer, Massachusetts Institute of
Technology, Cambridge, MA
Dr. Karen Wooley,
Washington University, St. Louis, MO
Dr. Andre Nel,
University of California Los Angeles, Los Angeles, CA
Dr. Vladimir Torchilin, Northwestern Univerisity, Boston,
MA |
| Facilities |
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Core A: Bioimaging, Core Director: Dr. Michael Boska
Core B: Nanomaterials, Core
Co-Directors: Dr. Alexander Kabanov, Dr. Tatiana
Bronich |
| Faculty |
| Events |
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5 COBRE Seed Projects Awarded in October
2009 (see updated list under "Projects" on the right-hand
side). |
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Overview
This COBRE has been funded to create the Nebraska
Center for Nanomedicine (NCN), a Center of Biomedical Research Excellence
(COBRE).
Nanomedicine is a rapidly developing area of
biomedical research that uses devices of nanoscale size to address urgent needs
for improved drug and gene delivery. Such “next generation” therapies can
specifically deliver drugs and recombinant DNAs to focal areas of disease or to
tumors to maximize clinical benefit while limiting untoward side effects. Such
nanotechnologies are expected to drastically improve early diagnosis through
bioimaging techniques. This parallels the road map for the National Institutes
of Health (NIH) where nanomedicine was identified as a development initiative
for the next decade. In keeping with these ideas, the Center will serve to join
already strong areas of biomedical and material science research into an even
stronger unit. Such goals can now be realized with the established expertise in
biomedical sciences (neuroscience, pathology, immunology, pharmacology,
immunization and cancer biology) and those in the material sciences
(nanomaterials, polymers, drug delivery, and gene delivery) within the
University of Nebraska Medical Center (UNMC).
Mission
The primary
goal of this COBRE is to provide a foundation for synergistic research
activities and translating the efforts into clinical benefit for diseases with
limited treatment options while simultaneously developing a potentially
“visionary” area of science where the State of Nebraska can emerge as a
world-leader. |
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Projects
Project 1:
“Nanofurmulations of Redox Enzymes for Treatment of Ischemic Stroke”
Project
Leader: Dr. Elena Batrakova, Mentor: Dr. Howard
Gendelman
Project 2: “A
Nanosyme Antioxidant Therapy for the Treatment of Angiotensin II-dependent
Hypertension”
Project Leader: Dr. Matthew Zimmerman, Mentor: Dr.
Irving Zucker
Project 3:
“Cell-based Nanoformulations for Brain Tumors”
Project Leader: Dr.
Huanyu Dou, Mentor: Dr. Surinder Batra
Project 4:
“Targeted nanocarrier for siRNA Delivery to Tumor Vasculature”
Project
Leader: Dr. Joseph Vetro, Mentor: Dr. Alexander
Kabanov
Seed Project 1: “Development of Cleavable
Polymer Micelles for Enhanced Diagnostic Imaging and Radiotherapy”
Project
Leader: Jered Garrison
Seed Project 2: “Anti-viral peptide
nanocomplexes (APN) for treatment of HIV/HCV co-infection”
Project
Leader: Larisa Poluektova
Seed Project 3: “Therapeutic modulation
of Erb B2-endocytosis pathways for targeted drug delivery”
Project
Leader: Srikumar Raja
Seed Project 4: “Novel Click
PEG-Dexamethasone Conjugate for the Treatment of Lupus Nephritis”
Project
Co-Leaders: Karen Gould and Xinming Liu
Seed Project 5: "Efficacy of Superoxide
Dismutase Polymer Conjugates for the Treatment of Oxidative Damage Induced by
Traumatic Brain Injury"
Project Leader: Matthew
Kelso
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