COBRE Nebraska Center for Nanomedicine
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Tatiana K. Bronich, Ph.D.
Parke-Davis Professor of Pharmaceutical Sciences Co-Director, Center for Drug Delivery and Nanomedicine Director, COBRE Nebraska Center for Nanomedicine University of Nebraska Medical Center
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Overview: This COBRE has been funded to create the Nebraska Center for Nanomedicine (NCN), a Center of Biomedical Research Excellence (COBRE). Nanomedicine is a rapidly developing area of biomedical research that uses devices of nanoscale size to address urgent needs for improved drug and gene delivery. Such "next generation" therapies can specifically deliver drugs and recombinant DNAs to focal areas of disease or to tumors to maximize clinical benefit while limiting untoward side effects. Such nanotechnologies are expected to drastically improve early diagnosis through bioimaging techniques. This parallels the road map for the National Institutes of Health (NIH) where nanomedicine was identified as a development initiative for the next decade. In keeping with these ideas, the Center will serve to join already strong areas of biomedical and material science research into an even stronger unit. Such goals can now be realized with the established expertise in biomedical sciences (neuroscience, pathology, immunology, pharmacology, immunization and cancer biology) and those in the material sciences (nanomaterials, polymers, drug delivery, and gene delivery) within the University of Nebraska Medical Center (UNMC).
Mission: The primary goal of this COBRE is to provide a foundation for synergistic research activities and translating the efforts into clinical benefit for diseases with limited treatment options while simultaneously developing a potentially "visionary" area of science where the State of Nebraska can emerge as a world-leader.
The COBRE Nebraska Center for Nanomedicine is supported by the National Institute of General Medical Science (NIGMS) grant 5P30 GM127200-03.
COBRE Projects
Project 1
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"Development of a Pretargeted Theranostic Nanomedicine for Ovarian Cancer"
Project Leader: Dr. Jered Garrison
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Project 2
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"Exploration of the anti-tumorigenic effects of chol-miR-1253 polyplexes in medulloblastoma"
Project Leader: Dr. Sidharth Mahapatra Mentor:
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Project 3
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“Evaluation of clinically relevant models for antifibrotic nanoparticle testing”
Project Leader: Dr. Benita McVicker Mentor:
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Project 4
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"Development of nanomedicine to accelerate the delayed fracture healing among chronic smokers"
Project Leader: Dr. Dong Wang Mentor:
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Project 5 
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“High Throughput iPSC Reprogramming with Controlled Single Cell Electroporation”
Project Leader: Dr. Ruiguo Yang Mentor:
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COBRE Core Facilities
COBRE Pilot Projects
Pilot Project 1

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UNL Pilot Grant
Project Leader: Dr. Forrest Kievit
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Pilot Project 2

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Nebraska Center for Nanomedicine - Zhang Pilot
Project Leader: Dr. Chi Zhang
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Pilot Project 3

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"Combined CXCR4 and microRNA inhibition to treat cholangiocarcinoma"
Project Leader: Dr. Justin Mott
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Pilot Project 4
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To be announced
Project Leader: |
Pilot Project 5
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To be announced
Project Leader:
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COBRE Alumni
Project: Multifunctional nanfiber skin graft for extensive skin replacement therapy"
Project Leader: Dr. Jingwei Xie
Project: “Nanoparticle formulations for Orlistat delivery to enhance efficacy of treatment of prostate cancer”
Project Leader: Dr. Aaron Mohs
Project: "Stable SERS-based multiplex nanosensors for early detection of cancer biomarkers"
Project Leader: Dr. Alexey Krasnoslobodtsev
Project: "Synthesis of Novel Self-Assembling Materials with Antibacterial Properties"
Project Leader: Dr. Martin Conda Sheridan
Project: "Targeting of a radio-sensitizer to prostate cancer"
Project Leader: Dr. Rebecca Deegan
Pilot project: UNL Pilot Grant
Project Leader: Dr. Forrest Kievit
Pilot project: Nebraska Center for Nanomedicine - Zhang Pilot
Project Leader: Dr. Chi Zhang
Pilot project: "Combined CXCR4 and microRNA inhibition to treat cholangiocarcinoma"
Project Leader: Dr. Justin Mott
Seed Project: “Therapeutic modulation of Erb B2-endocytosis pathways for targeted drug delivery”
Project Leader: Srikumar Raja
Seed Project: “Novel Click PEG-Dexamethasone Conjugate for the Treatment of Lupus Nephritis”
Project Co-Leaders: Karen Gould and Xinming Liu
Project: “Nanoformulations of Redox Enzymes for Treatment of Ischemic Stroke”
Project Leader: Elena Batrakova
Seed Project: “Macromolecular Therapy for Improved Treatment of Lupus Nephritis”
Project Co-Leaders: Karen Gould and Dong Wang
Seed Project: "Molecular Basis for Copolymer Nanoparticles-Caveolae Interactions to Design Generic Anticancer Delivery System"
Project Leader: Sorin Luca
Seed Project: “Macromolecular Prodrug Development for the Treatment of Lupus Nephritis”
Project Co-Leaders: Dong Wang and Karen Gould
Seed Project: “Effect of Nanozymes in Modulating AT-Oxidative Stress and Inflammation in Obesity”
Project Leader: Saraswathi Viswanathan
Seed Project: “Free Radicals in Medicine Pilot”
Project Leader: Srikumar Raja
Seed Project: “Free Radicals in Medicine Pilot”
Project Leader: Dee Harrison-Findik
Seed Project: “Application of Pluronic Block Copolymers to Relapsed/Refractory Multiple Myeloma”
Project Leader: Edward Faber, Jr.
Project: "Neuroprotective Regulatory T Cells as Vehicles for Nanoformulated Growth Factor Delivery to an Injured Brain"
Project Leader: Dr. Matthew Kelso
Seed Project: “Local Sustained Co-delivery of 25-Hydroxyvitamin D3 and Parathyroid Hormone-related Peptide for Prevention of Surgical Site Infection”
Project Leader: Jingwei Xie
Project: "Development of Metabolically Active Linkers (MALs) to Improve Diagnostic and Radiotherapeutic HPMA Copolymers"
Project Leader: Dr. Jered Garrison
Mentor: Dr. Surinder Batra
Project: “MUC4-based Vaccine for Pancreatic Cancer”
Project Leader: Dr. Maneesh Jain
Mentor: Dr. Joyce Solheim
Project: “Renal Nanovaccine Vaccine for Pancreatic Cancer”
Project Leader: Dr. Karen Gould
Mentor: Dr. Tatiana Bronich
Project: “The Role of Nanoformulated Cu/ZnSOD in Reducing Systemic Hypertension in Obesity”
Project Leader: Dr. Saraswathi Viswanathan
Mentor: Dr. Irving Zucker
COBRE External Advisory Committee